Djokovic, Federer US Open showdown looms

Novak Djokovic and Richard Gasquet

Novak Djokovic is on to the US Open quarterfinals - and potentially a showdown with Roger Federer.

A shocked Bill Clinton was on hand Monday night to watch as Roger Federer got knocked out of the US Open's 4th round in one of the biggest upsets in recent history.

He improved to 28-0 at the US Open against opponents ranked outside the top 50, and here's another reason it wasn't all that surprising the way things went against Sousa: Djokovic is now 5-0 in their head-to-head series, taking all 14 sets they've played against each other.

Sousa arrived at the season's final Grand Slam in awful form having lost his last seven matches but suddenly found his game on the Flushing Meadows hardcourts knocking off two seeded players, number 12 Pablo Carreno Busta and number 17 Lucas Pouille, on route to the last 16.

Both Nishikori and Djokovic missed last year's US Open with arm injuries.

Nishikori will next face either seventh seed Marin Cilic, which will be a rematch of the 2014 final, or Belgian 10th seed David Goffin.

Now he meets Djokovic in his first Grand Slam quarter-final on Wednesday.

Information from The Associated Press was used in this report.

Japan's Kei Nishikori also reached the last eight, beating Philipp Kohlschreiber 6-3, 6-2, 7-5.

Roger Federer says he has enormous respect for John Millman ahead of their US Open fourth-round clash at Flushing Meadows after the pair trained together in the lead-up to the grass-court season.

In the women's draw, Madison Keys eased into the quarter-finals with a 6-1, 6-3 victory over Slovakia's Dominika Cibulkova.

Keys was an Open finalist a year ago and lost to Sloane Stephens. She was broken in six of her 10 service games.

Tsurenko struggled in the heat. Two games later, Keys reached match point, and although she lost the first by netting a return, she garnered a second after a Cibulkova drop shot attempt found the net. She still and looked tired to start the second, leaning on her racket between points while falling behind 2-0.

"I felt like a bit of a deer in headlights to begin with, to be honest with you", Millman said. 'The balls where I did attack, I made unforced errors, especially on that inside-out forehand today'.

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